In the article to assess the continentality of the region’s climate at 10 stations in the Lower Volga region, the annual air temperature amplitudes were calculated, and the climate continentality indices were determined according to 5 formulas of different authors. The carried out calculation allows to allocate Zavolzhsky areas of the Saratov and Volgograd areas in region with as much as possible favorable conditions on cultivation of high-protein wheat.