The article considers the features of the gasometric survey and seismic exploring results on the regional geophysic profile in territory of the large geostructual blocks on south-eastern part of Russian platform: Voronezh anticlise, Rjazano-Saratov’s deflection and Zhiguljov-Pugachov deflection. It selected testes of gas from 2m depth there are metan, its gomologes, hydrogen, gelium. In gas anomalies the fractured tectonic and geostructured elements reflected. Its presents the oil-gas prospecting interest.